An examination of Figure 1 with R2 0.969 (N = 15) and Figure 10 with R2 0.999 (N = 6 including APOE) would suggest that the noncoding RNA assembly process in Late-onset Alzheimer's disease would involve relatively highly systematic process or processes as compared to familial early-onset Alzheimer's disease with APP, PSEN1, PSEN2, and APOE. Here, APP is linked to early-onset autosomal dominant Alzheimer disease.