Many other missense mutations in SCN1A also contribute to Dravet's Syndrome, but most of the complications of Dravet's Syndrome result from SCN1A mutations caused by frame shift, nonsense, and splice-site mutations, which lead to a truncated protein and haploinsufficiency of SCN1A [86–90, 109, 110]. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.