TIMP2 and sarcoma: For example, when Benassi et al examined biopsied tissue immunohistochemically from patients with soft tissue sarcomas, he noted that poor prognosis was significantly correlated with elevated MMP-2 and lack of TIMP-2 expression in all sarcomas studied and that elevated MMP-2 and MMP-9 levels significantly correlated with metastasis in liposarcoma (17).