In this in vitro study, the NM significantly inhibited secretion of u-PA and MMP-2 and/or -9 and increased secretion of TIMP-2 in fibrosarcoma, chondrosarcoma, liposarcoma and uterine leiomyosarcoma cells, suggesting its potential in modulating cancer invasion and metastasis. The gene discussed is PLAU; the disease is chondrosarcoma.