INS and hyperinsulinemic hypoglycemia, familial, 4: The five patients with confirmed absolute deficiency on MMTT had a lower BMI (BMI 25.1 vs. 29.1 kg/m2, P=0.04), and commenced insulin treatment more rapidly after diagnosis (2.5 vs. 6 years, P=0.005), although there was substantial overlap for both these measures between those with (n=5) and without (n=167) absolute insulin deficiency.