KCNJ11 and serum lipopolysaccharide activity: That loss of Kir6.2 subunits aggravates endotoxemia-induced cardiac dysfunction is suggestive of a previously unrecognized biological role of this subunit in regulating the cardiac function, and Kir6.2 subunits of KATP channels may play an important role in resistance to endotoxemia-induced cardiac dysfunction.