Thus, despite their inherent relationship in the processes of water transport in the previously mentioned conditions (edema reabsorption, meningitis, hydrocephalus), AQP4, by means of connexin-43 (Cx43) regulation, is also a modulator of the formation and development of the gap junctions in the ependymal basolateral membrane and astrocyte feet. The gene discussed is GJA1; the disease is Hydrocephalus.