Thus, despite their inherent relationship in the processes of water transport in the previously mentioned conditions (edema reabsorption, meningitis, hydrocephalus), AQP4, by means of connexin-43 (Cx43) regulation, is also a modulator of the formation and development of the gap junctions in the ependymal basolateral membrane and astrocyte feet. Here, GJA1 is linked to infectious meningitis.