The authors examined the association between several SNPs in PI3Ks genes (PIK3CD, PIK3C2A, PIK3R3, PIK3AP1, and PIK3C2B) and prostate cancer risk: among the five genes, only PIK3C2B showed a cluster of SNPs related to prostate cancer risk. The gene discussed is PIK3C2B; the disease is Familial prostate cancer.