Mutations and/or amplifications of the PI3K catalytic subunits p110α (PIK3CA) and p110β (PIK3CB), the PI3K regulatory subunits p85α (PIK3R1) and p85β (PIK3R2), the PI3K effector AKT (AKT1) are often observed in cancer.1 The gene discussed is PIK3CA; the disease is cancer.