CRH and Anorexia: “Pathologic” anorexia is a consequence of intercurrent illnesses like cancer (as cytokines deriving from tumor tissue may act as important anorexing agents), chronic pulmonary obstructive disease (difficult respiration during the meal consumption), cerebral ischemic attacks (difficulty swallowing), abdominal angina (severe abdominal pain after a meal), chronic constipation (causing a feeling of fullness), dementia (indifference to food) and depressive syndromes (anorexia might be linked to the increase of the hypothalamic corticotropin releasing factor).