PTX3 and chronic kidney disease: Moreover, our analyses revealed no significant differences in the adipose tissue PTX3 mRNA levels between the CKD-5 patients and non-CKD controls, indicating no obvious uremic-related abnormalities in the adipose tissue expression levels of PTX3. Instead, our results from transplanted patients support the notion that reduced clearance is a pivotal factor contributing to the elevated systemic PTX3 levels when renal function declines.