In the present work, we have shown that 1) galectin-7 is rarely expressed in biopsies of malignant melanoma, 2) galectin-7 reduces the motility of B16F1 cells, and 3) galectin-7 increases the resistance of B16F1 cells to apoptosis and the expression of EGR-1. Here, LGALS7 is linked to melanoma.