Beclin1, the mammalian orthologue of Atg6, promotes autophagy in human breast carcinoma MCF-7 cells [30], by localizing at the trans-Golgi network and participates in the initial steps of vesicle nucleation through forming a complex with the class III phosphatidylinositol 3-kinase (PI3K) [31]. Here, BECN1 is linked to breast carcinoma.