Our prior experimental results have provided demonstration of the physiopathological role of eNOS in three cellular contexts: normal human endothelial cells (HUVEC) before and after treatment with 17β-estradiol (E2); epithelial cell cultures from PCa explants grown in basal condition or with E2; and prostate tissue specimens from PCa patients. The gene discussed is NOS3; the disease is posterior cortical atrophy.