ERBB2 and metastatic malignant neoplasm in the lymph nodes: In our study, elevated flotillin2 and HER2 both showed a significant correlation with histologic type (P<0.001 both), Lauren grade (P<0.001 both), whereas flotillin2 also get a high relevance with T stage (P<0.001) and lymph node metastasis (P = 0.033).