IL-6 treatment of NP460hTert-EBV cells (EBV-infected NPE cells), C666-1 (EBV-positive NPC cells) and HONE-EBV (EBV-reinfected NPC cells) all resulted in upregulation of LMP1 transcription (Figure 4B). This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.