Infusion of insulin at 5 mUnits/min over a 60 minute period lead to a significant increase in FBF in healthy controls from 3.4±0.4 to 5.0±0.7 mL.min−1.100 mL−1 (p<0.001), whilst in diabetics there was a small although non-significant rise from 2.7±0.5 to 3.6±0.6 mL.min−1.100 mL−1 (p = ns) (Figure 1A). Here, INS is linked to diabetes mellitus.