Surface CD133, also known as prominin-1, is a cell-surface transmembrane glycoprotein that has been used in the identification of putative CSCs in several malignant tumors, because they have shown increased tumorigenic potential in transplantation studies in vitro and in vivo[34]–[36], as well as an association with poor prognoses and distant metastases [37], [38]. The gene discussed is PROM1; the disease is cancer.