The association with integrins and invasion is particularly noteworthy since CD97 has been shown to demonstrate strong interactions with integrin α5β1, which is expressed in GBM and other cancers [37]; coengagement of CD97 with both chondroitin sulfate, a component of the ECM, and α5β1 synergistically initiates endothelial cell invasion [17]. The gene discussed is ADGRE2; the disease is glioblastoma.