CXCL10 and viral infectious disease: IRF-3 serves as an essential transcriptional activator for type I interferons (IFNα/β), a subset of interferon-stimulated genes as well as some chemokine genes such as RANTES and CXCL10/IP-10 and plays critical roles both in the innate immune response against viral infection and the subsequent activation of adaptive immunity [27]–[31].