Our immunohistochemical staining results showed that the expression levels of hnRNP A1/A2 and SF2/ASF were significantly elevated in human NSCLC tumor tissues and bronchiectasis tissues compared with non-tumor control tissues, indicating a correlation of hnRNP A1/A2 and SF2/ASF over-expression with inflammatory diseases and tumorigenesis of human NSCLC. Here, SRSF1 is linked to bronchiectasis.