Since silencing hnRNP A1/A2 or SF2/ASF in human NSCLC cells reduced expression levels of IRF-3 protein, we next examined the expression of hnRNP A1/A2, SF2/ASF, and IRF-3 in 63 NSCLC tumor tissues, 39 non-tumor control tissues, and 26 bronchiectasis tissues. The gene discussed is IRF3; the disease is bronchiectasis.