MYC and lymphoma: Previous studies suggested that the oncogenic transcription factor c-Myc has a crucial role in cell growth, metabolism and proliferation [57], Cyclin dependent kinase 6 (CDK6) overexpression was implicated in the pathogenesis of B-cell malignancies [58], and also aberrant expression of the cell cycle regulatory protein Cyclin B1 has been detected in different lymphomas and EBV-immortalized cells [59], [60].