Positioned downstream in the FA pathway are the breast cancer–associated proteins FANCD1/BRCA2 (breast cancer–associated protein 2), FANCN/PALB2 (partner and localizer of BRCA2) and FANCJ (BRIP1, BRCA1-interacting protein 1) that function in homologous recombination (HR) repair of DNA double-stranded breaks (DNA DSBs) (16,17). The gene discussed is BRIP1; the disease is breast carcinoma.