In the present study, BTG3 protein expression was positively linked to clinicopathological features of ovarian carcinoma, including differentiation and FIGO staging in agreement with the data of our real-time RT–PCR, indicating that BTG3 might be involved in the development and differentiation of EOC and be considered as a good biomarker to indicate the aggressive behaviors of EOC. Here, BTG3 is linked to ovarian carcinoma.