In a case-control cross-sectional study, Reis et al. demonstrated that aggravation of hypertension in preeclampsia correlates with serum atrial natriuretic peptide (ANP) and brain naturiuretic peptide (BNP) concentrations, although BNP values may be influenced by the existence of a prior hypertensive state.6 This evidence concerns the gene NPPB and Hypertension.