Presently, we cannot dismiss the possibility that the protective effect of SGE-3X could be mediated by MAX; however, several other proteins (LJM17 and LJM11 in human and LJM17, LJM11, LJL13, LJL23 and LJL143 in dogs) from L. longipalpis saliva have been identified[41], suggesting that intensive efforts are required for the identification of salivary compounds responsible for the protective effect of sand fly saliva on leishmaniasis. The gene discussed is MAX; the disease is leishmaniasis.