There exist a few examples where CLECs have been implicated in CNS pathology, for example, Clec16a has been genetically associated with susceptibility to multiple sclerosis (MS) [48] and is upregulated in astrocytes after infectious stimuli [49], and Clec5a was recently demonstrated to have a disease regulatory effect in a mouse viral encephalitis model [50]. Here, CLEC5A is linked to viral encephalitis.