IGHE and Airway obstruction: For chronic lung diseases such as asthma, an effective model should reproduce the principal aspects of human asthma, which include immunoglobulin E (IgE)-mediated sensitivity to antigens, acute bronchoconstriction, increased airway resistance, chronic inflammation of the airways, Th2 cytokine production, eosinophilia, late phase airway obstruction, enhanced mucus secretion, decreased mucociliary clearance, airway wall remodelling, and smooth muscle hyperplasia [11].