IGHE and Airway obstruction: Herd et al. [41] reported that neonatal rabbits immunised within 24 h of birth [41] exhibited many features of human asthma, including AHR in response to inhaled antigen, acute and late phase airway obstruction [24], pulmonary eosinophil and lymphocyte recruitment [41, 42], and production of IgE antibodies [24, 43].