We have made the novel observations that (i) the SAT in subjects with nascent MetS has increased macrophage recruitment with CLS in greater abundance; (ii) the SAT in subjects with nascent MetS produces increased levels of biomarkers that correlate with both insulin resistance and low-grade inflammation, potentially presaging the subsequent increased risk for diabetes and CVD; and (iii) there is a dysregulation in both SAT-derived chemerin and omentin-1 in subjects with nascent MetS, suggesting a possible role of these adipokines in both diabetes and CVD. The gene discussed is RARRES2; the disease is Insulin resistance.