RIGI and infection: Together, our current data show that RNA of the facultative intracellular bacterium L. monocytogenes has quantitative access to the cytosol of the host cell, and that detection of bacterial RNA by the cytosolic immune receptor RIG-I plays a non-redundant role in non-immune cells with impaired DNA/c-di-AMP (STING dependent) recognition pathway such as hepatocytes, a cell type involved in the propagation of bacteria in chronic infection, and colon epithelial cells, a cell type that is critically involved in the enteral route of infection.