By contrast, in THP-1 cells, which can recognize bacDNA and bacRNA, type I IFN induction did not appear to be influenced by siRNA-mediated knockdown of MAVS during infection with L. monocytogenes (Fig. 4C), while the type I IFN response to the RIG-I ligand 3P-dsRNA was efficiently downregulated. Here, MAVS is linked to infection.