Comparing CA 15.3 and CEA tumour markers in NBM versus BM patients revealed that only CEA showed a significant (p < 0.05) increase in BM group; however, after redistributing the patients into three groups, we found that CA15.3 was significantly higher (p < 0.01) in the new BM group as compared with free BM and BM groups. This evidence concerns the gene CEACAM5 and neoplasm.