TNF and rheumatoid arthritis: In this study, we clarified that the synergistic effects among six main ingredients in QLY are caused by acting on the compensatory pathway and feedback loop in the TNF/IL1B/VEGF-induced NF-κB pathways involved in RA and the synergistic mechanism of QLY is partially associated with the modulation of NF-κB imbalanced network (Figures 3 and 4).