TNFSF10 and hyperinsulinemic hypoglycemia, familial, 4: Only TNF-related apoptosis-inducing ligand (TRAIL) deficiency/ soluble DR5 (TRAIL antagonist), type I interferon receptor deficiency (IFNABR−/−), and granzyme deficiency [37, 38, 156–158] reduced T cell apoptosis in vivo following infection, suggesting they are involved.