Plasma concentrations of high-sensitivity C-reactive protein (hs-CRP), fibrinogen, and plasminogen activator inhibitor-1 (PAI-1) activity were found markedly lower in nonobese healthy volunteers, intermediate in overweight nonsteatotic patients, and the highest in overweight subjects with biopsy-proven NASH, after adjustment for age, BMI, smoking, plasma triglycerides, and insulin resistance [25]. This evidence concerns the gene INS and metabolic dysfunction-associated steatohepatitis.