Interestingly, mitophagy requires genes that have been implicated in the neurodegenerative Parkinson’s disease, i.e., the serine/threonine kinase PINK1 and the E3 ubiquitin ligase Parkin, where PINK1 senses the damaged mitochondria and recruits Parkin to induce mitophagy (Narendra et al., 2008, 2010). This evidence concerns the gene PRKN and Parkinson disease.