GRM2 and schizophrenia: Although the cortical binding density of the mGluR2/mGluR3 selective ligand, [3H]LY354740, is reported to be unaltered in schizophrenia (Frank et al., 2011), cortical binding of [3H]LY341495, another mGluR2/mGluR3 selective ligand, and mGluR2 but not mGluR3 mRNA has been reported to be decreased in subjects with schizophrenia, 84% of whom died by suicide (Gonzalez-Maeso et al., 2008).