TEK and neoplasm: In pre-clinical models, there is strong evidence to show that TIE2-expressing monocytes/macrophages (TEMs) support angiogenesis in tumours and remodelling tissues (Capobianco et al, 2011; Coffelt et al, 2010; De Palma et al, 2005; Fantin et al, 2010; He et al, 2012; Mazzieri et al, 2011; Modarai et al, 2005; Pucci et al, 2009), but there is a paucity of data linking this cell type to pathologies in patients.