Part of this variability in the CML CD34+CD38−ALDHhigh fraction could be accounted for by the presence of residual BCR-ABL negative normal HSC in this cell population; the two subjects with the highest fraction of residual normal HSC clustered most closely with the normal HSC (Figure 1; Supplementary Table 1). Here, CD34 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.