To further analyze our list of potential LSC-specific targets, functional annotation by the Database for Annotation, Visualization, and Integrated Discovery (DAVID) of genes differentially expressed on the CML versus normal CD34+CD38−ALDHhigh cells (FDR = 0.05, |log2(Fold Change)| > 1); represented by () in Figure 2) was carried out and highlighted several plasma membrane-associated genes (GO:0044459, Plasma Membrane Part), including the most up- and down-regulated genes, DPP4 and CDH2, respectively (Table 1). Here, DPP4 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.