Although epidemiology studies tend to show a positive relationship between TCDD body burdens and insulin levels (Cranmer et al. 2000; Michalek et al. 1999), TCDD typically causes hypoinsulinemia and increased insulin sensitivity in animals (Ebner et al. 1988; Fried et al. 2010; Gorski et al. 1988; Gorski and Rozman 1987; Potter et al. 1983; Stahl et al. 1992; Weber et al. 1987). The gene discussed is INS; the disease is Hypoinsulinemia.