8 days repeated IL-1-induced memory impairment was reversed by IL-1RA treatment (day 5, F1,18 = 7.53, P <0.05; day 6, F1,18 = 8.61, P <0.01; day 7, F1,18 = 10.32, P <0.01; day 8, F1,18 = 8.74, P <0.01) (Figure 1B). The gene discussed is IL1B; the disease is memory impairment.