Although some other models of retinal degeneration exhibit mislocalization of OS proteins as part of the degenerative process [31], [32], here we saw no mislocalization of transgenic RDS (Fig. 1C), total RDS (the RDS-CT antibody recognizes both transgenic and endogenous RDS, Fig. 3A), the RDS binding partner ROM-1 (Fig. 3B), rhodopsin (Fig. 3C) or S- and M-cone opsins (Fig. 3D–E). Here, RHO is linked to retinal degeneration.