Analogous to the gene expression profile employed by Brown et al. to characterize the phenotype of the vascular stroma in different kinds of breast cancer [3], and the “tripartite arrangement of an invasive carcinoma cell, a macrophage, and an endothelial cell” proposed by Robinson et al. of [45] as a potential prognostic marker of metastasis in human breast cancer, here we were able to characterize the “metastatic signature” of transgenic human breast cancer cell lines engineered to overexpress VEGF-A using in vivo MRI parameters. Here, VEGFA is linked to invasive carcinoma.