Prior in vivo MRI studies of VEGF overexpressing cancer cells have been conducted in in C6-pTET-VEGF165 xenografts inoculated in the mouse hind limb [15], or have demonstrated that the acute response of the tumor vasculature to intradermally administered VEGF165 was vasodilation, hyperpermeability and lymphatic uptake [39]. Here, VEGFA is linked to neoplasm.