In the present study, we confirmed that LPLUNC1 was down-regulated in NPC and found that LPLUNC1 inhibited NPC cell growth in vitro and in vivo, through cell cycle arrest at G0-G1 phase; therefore LPLUNC1 may play an important role in the carcinogenesis of NPC. This evidence concerns the gene BPIFB1 and nasopharyngeal carcinoma.