KRAS and pachyonychia congenita: To assess the chemotherapeutic potential of P-V, we employed both orthotopic and heterotopic (subcutaneous) PC xenograft models in nude mice using two human PC cell lines differing in their Kras status, BxPC-3 (wild-type Kras) and MIA PaCa-2 (mutant Kras) (Fig. 1B–D).