LMNB1 and adult-onset autosomal dominant demyelinating leukodystrophy: In contrast to previous reports, we show that LMNB1 duplications can have a heterogeneous architecture with the first description of an inversion involving LMNB1. We propose that the genomic architecture, including the enrichment of Alu repetitive elements and higher GC%, especially in the genomic region centromeric to the LMNB1 gene may play an important role in mediating the ADLD duplications.