We document here that co-administration of LPS/PepG or sepsis caused no changes in the phosphorylation of Akt on Ser473 in heart and liver tissues, but treatment of mice with IKK 16 at 1 hour after co-administration of LPS/PepG or CLP resulted in a significantly increased phosphorylation of Akt, and, hence, activation of Akt. This evidence concerns the gene AKT1 and Sepsis.