NOS2 and septic shock: Subsequently, NF-κB-dependent proteins are less expressed, e.g. iNOS (which plays a crucial role in the hypotension and MOD associated with septic shock) (Barth et al., 2006; Brady et al., 1992; Kengatharan et al., 1996; Szabó et al., 1994; Thiemermann and Vane, 1990).