In contrast to altered AKT activation, probing of blots with phospho-ERK 1 and 2 antibodies for active MAPK indicated that levels of phosphorylated (active) ERKs were no different in control and rODAM-expressing melanoma cells suggesting that signaling through this pathway is not directly altered by ODAM expression under these culture conditions (Figure 3B). The gene discussed is ODAM; the disease is melanoma.