In a multivariate analysis incorporating all clinicopathologic variables and covariates as shown in Table 3, comparisons between genders ages, tumor grades, tumor T stages, tumor C stages, expression levels of Nanog protein (low vs. high), and intracellular β-catenin protein expression at the membrane, in cytoplasm and in the nucleus (low vs. high) were performed to identify independent prognostic factors. The gene discussed is NANOG; the disease is neoplasm.