BDNF and neoplasm: As miR-1 has multiple experimentally validated targets from this study (Ets1, Met, Bag4) and from published studies (MET, PTK1, HDAC4, ANXA2, BDNF and FOXP1) that have roles in tumorigenesis, it is likely that miR-1’s ability to reduce the expression of many tumor promoting genes could have a global influence on the suppression of tumor development (Nasser et al., 2008; Datta et al., 2008; Yan et al., 2009; Reid et al., 2012).