HCRT and narcolepsy: Some narcolepsy without cataplexy patients have been reported to exhibit down-regulation of lumbar cerebrospinal fluid hypocretin-1 level (Bourgin, Zeitzer & Mignot, 2008) and hypothalamic peptides hypocretin/orexin has been reported to contribute to the intrusion of REM sleep behaviors into wakefulness by coordinating the activity of RAS through hypocretin/orexin neuron during waking stage (Burlet, Tyler & Leonard, 2002).