PMCH and major depressive disorder: In addition to regulation of feeding, the melanin-concentrating hormone (MCH) system is an important regulator of a number of behaviors related to reward processing, addiction and other neuropsychiatric conditions such as schizophrenia and depression (Georgescu et al., 2005; Nestler & Carlezon, 2006; Shirayama & Chaki, 2006; Chung et al., 2009; Morganstern et al., 2010; Sears et al., 2010; Mul et al., 2011; Chung et al., 2011a; Chung et al., 2011b).