Apomorphine within the NAshell can also reduce withdrawal-related anxiety (Radke & Gewirtz, 2012), suggesting that this mechanism might be relevant to other psychiatric diseases such as depression which are modulated through MCH (Georgescu et al., 2005; Nestler & Carlezon, 2006; Shirayama & Chaki, 2006; Chung et al., 2009; Morganstern et al., 2010; Sears et al., 2010; Mul et al., 2011; Chung et al., 2011a; Chung et al., 2011b). Here, PMCH is linked to major depressive disorder.