PTGS2 and cancer: Pretreatment of cancer cells with the COX-2 inhibitor, the EP4 antagonist, or mTOR inhibitor, significantly inhibited 8-CPT-2Me-cAMP-induced protein synthesis (Figure 2A) consistent with the recent report that PGE2 regulates mTORC1 and mTORC2 signaling [42], [43].