It is believed that severe malaria is caused by a combination of parasitic factors and high levels of proinflammatory cytokines such as tumor necrosis factor (TNF)-α, lymphotoxin-α, interferon (IFN)-γ [4]–[6] as well as different effector cells such as CD4+ T cells, CD8+ T cells, natural killer T cells, and natural killer cells [7]–[11]. The gene discussed is CD4; the disease is malaria.